F Mariani, D. Goletti, A. Ciaramella, A. Martino, V. Colizzi and M. Fraziano Pages 209 - 216 ( 8 )
Human macrophages represent the first line of defense for the containment of Mycobacterium tuberculosis infection. After phagocytosis, macrophages express activation surface markers and produce proinflammatory cytokines and chemokines whose main role is to control pathogen spreading by recruiting peripheral lymphocytes and monocytes at the site of inflammation. However, in the case of a concomitant human immunodeficiency virus (HIV) infection, these signals strongly enhance the susceptibility to viral infection both at the viral entry and replication levels. Under these conditions, viral expansion extends beyond tissue macrophages to T cells and vice-versa, according to the emerging viral phenotype. In absence of an efficient immune response, Mycobacterium tuberculosis can replicate in macrophages in an uncontrolled fashion culminating in macrophage death by apoptosis. As a consequence, a more severe form of immunedepression, involving both innate and specific immune responses, could be responsible for both ematogenous mycobacterial dissemination and extrapulmonary form of tuberculosis in HIV-infected patients.
Macrophage Response, Mycobacterium tuberculosis, Apoptosis, proinflammatory cytokines, chemokines, HIV REPLICATION, BACILLI REPLICATION, T LYMPHOCYTE DEP-LETION, MACROPHAGE APOPTOSIS, Acquired immunodeficiency syndrome
Laboratory of Immunochemistry and Molecular Pathology, University of Rome Tor Vergata , Via della Ricerca Scientifica - 00133 - Rome - Italy.