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Overcoming Immune Evasion in T Cell Therapy of Cancer: Lessons from Animal Models

[ Vol. 8 , Issue. 1 ]

Author(s):

Xue-Feng Bai and Jin-Qing Liu   Pages 68 - 75 ( 8 )

Abstract:


Cancer antigen-specific cytotoxic T lymphocytes (CTL) are the major effectors against cancer cells. However, large established tumors are usually not fully controlled by CTL for at least two reasons. First, large established tumors have immune suppressive networks that not only suppress CTL effector function but also permit tumor progression. Second, the genetic instability of cancer cells often results in the selection of antigenic variants by CTL, which allow cancer cells to escape destruction. Simply enhancing T cell capacity may not fully control large established tumors. Other measures, such as enhancing local costimulation, inhibiting angiogenesis and down-regulating functions of tumor associated myeloid cells should also be considered. In this paper we will review some of the progress from animal studies.

Keywords:

Cytotoxic T lymphocytes, adoptive T cell therapy, cancer immune evasion

Affiliation:

Department of Pathology and Comprehensive Cancer Center, The Ohio State University Medical Center,129 Hamilton Hall, 1645 Neil Avenue, Columbus,Ohio 43210, USA.



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