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Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) Ligands: Novel Pharmacological Agents in the Treatment of Ischemia Reperfusion Injury

[ Vol. 8 , Issue. 6 ]

Author(s):

Costas Giaginis, Gerasimos Tsourouflis and Stamatios Theocharis   Pages 562 - 579 ( 18 )

Abstract:


Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands constitute important insulin sensitizers that have already been used for the treatment of human metabolic disorders, exerting also pleiotropic effects on inflammatory related diseases and cancer. Ischemia-reperfusion injury that is mainly associated with organ transplantation constitutes a serious complication with a great relevance in clinical practice. Accumulating experimental data have recently revealed that natural and synthetic PPAR-γ ligands exert beneficial effects against ischemia-reperfusion injury. The present review summarizes the available information on the role of PPAR-γ ligands in ischemia-reperfusion injury amongst the different organ systems. Taking into consideration the data so far, PPAR-γ ligands seem to represent potential therapeutic agents in the aim to reduce or even prevent injury associated with ischemia-reperfusion.

Keywords:

Ischemia Reperfusion Injury, Peroxisome proliferator-activated receptor-γ (PPAR-γ), insulin sensitizers, human metabolic disorders, inflammatory, growth hormone protein-1 (GHP-1)

Affiliation:

Forensic Medicine and Toxicology, Medical School, National and Kapodistrian University of Athens, 75 M. Asias Str., Goudi, GR11527 Athens, Greece.



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