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Posttranscriptional Regulation of p53 and its Targets by RNABinding Proteins

[ Vol. 8 , Issue. 8 ]

Author(s):

Jin Zhang and Xinbin Chen   Pages 845 - 849 ( 5 )

Abstract:


p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

Keywords:

p53, posttranscriptional regulation, RNA-binding proteins, translational regulation, mRNA decay

Affiliation:

Tupper 2128, VM: Surgical and Radiological Sciences, University of California at Davis, Davis, CA 95616, USA.



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