J. Xiong Pages 247 - 258 ( 12 )
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that have critical regulatory functions in various biological processes. MicroRNA-22 (miR-22) is a highly-conserved 22-nt miRNA, whose roles in human diseases and normal physiology are just beginning to emerge. Recently, miR-22 has been connected to a great number of activities that encompass tumorigenesis, epigenetic modification, embryonic development, skeletal metabolism, panic disorder, and cardiomyocyte hypertrophy. Aberrant expression of miR-22 has been identified in multiple human diseases. Here, we describe our current understanding of the roles of miR-22 and its signaling circuitry in pathology and physiology, and discuss important advances that set the scene for applying miR-22 to the prevention and treatment of a wide range of human diseases.
Cancer, embryonic stem cell, microRNA, miR-22, skeletal metabolism, tumor suppressor, cell growth, apoptosis, oncogene, metabolic bone disease, osteoarthritis, panic disorder, cardiomyocyte hypertrophy, HeLa cells, gene expression
Laboratory of Nucleic Acid Technology, Institute of Molecular Medicine, Peking University, 5 Yiheyuan Road, Haidian District, Beijing 100871, China.